Teva Homepage Print this page Site Map
אודוΧͺ Χ˜Χ‘Χ’Χ§Χ©Χ¨Χ™ ΧžΧ©Χ§Χ™Χ’Χ™ΧΧžΧ’Χ•Χ¨Χ‘Χ•Χͺ Χ—Χ‘Χ¨ΧͺΧ™Χͺ

ηγωεϊ εδεγςεϊ μςιϊεπεϊ

ξηχψ περσ ξφαις ςμ ιςιμεϊ βαεδδ μθιτεμ αχετχρεο® αηεμιν ωςαψε ξθιτεμ αΰιπθψτψεο αθΰ

10/4/2008 ηεμι θψωϊ πτεφδ αωμα δδϊχτι (RRMS) ωςαψε ξθιτεμ αΰιπθψτψεο αθΰ μθιτεμ αχετχρεο® ηεε δτηϊδ ξωξςεϊιϊ αωιςεψ δδϊχτιν δωπϊι εδΰθδ αχφα δϊχγξεϊ δξημδ

θας δεγιςδ ςμ ϊεφΰεϊ ξηχψ αο ωμεω ωπιν, ωςχα ΰηψ ηεμι θψωϊ πτεφδ αωμα δδϊχτι (RRMS) ΰωψ δημιτε θιτεμ αςχαεϊ ΰι-δφμηϊ δθιτεμ δψΰωεο, δξψΰεϊ λι ηεμιν ωςαψε μθιτεμ αχετχρεο® ωμ θας μΰηψ ωθετμε αΰιπθψτψεο αθΰ (IFNb), ηεε ιψιγδ ξξεφςϊ ωμ 77% αωιςεψ δδϊχτιν δωπϊι (ξ-0.63 μ-0.14). απερσ, θιτεμ αχετχροο® ςιλα ΰϊ δϊτϊηεϊ δξεβαμεϊ δτιζιϊ ωμ ηεμιν ΰμε, λτι ωπξγγ αΰξφςεϊ ξγγ δ-EDSS. ϊεφΰεϊ δξηχψ τεψρξε αβιμιεο ΰτψιμ ωμ διψηεο European Journal of Neurology.

αξηχψ παγχδ διςιμεϊ δχμιπιϊ ωμ ξςαψ αιο θιτεμιν, αχψα ηεμι RRMS ωδημιτε θιτεμ ΰιξεπε-ξεγεμθεψι μΰηψ ωδθιτεμ δψΰωεο μΰ δωιβ ΰϊ ξθψεϊιε. ξϊεφΰεϊιε ςεμδ, λι λμ δηεμιν ηεε ιψιγδ αωιςεψ δδϊχτιν αςχαεϊ δημτϊ δθιτεμ. ςν ζΰϊ, πξφΰ λι αχψα ηεμιν ΰωψ ςαψε ξθιτεμ αΰιπθψτψεο αθΰ μθιτεμ αχετχρεο® μΰ πψωξδ δϊτϊηεϊ ξωξςεϊιϊ ωμ δξεβαμεϊ δτιζιϊ, αςεγ ωδξεβαμεϊ δτιζιϊ δξωιλδ μδϊτϊη αχψα ηεμιν ωςαψε ξχετχρεο® μΰιπθψτψεο αθΰ, ΰε δημιτε θιτεμ αιο ϊψετεϊ ωεπεϊ δξαερρεϊ ΰιπθψτψεο αθΰ.

δραψ ΰτωψι μϊεφΰεϊ ΰμε διπε δϊτϊηεϊ πεβγπιν ξπθψμιν (NAbs) αχψα ηεμιν δξθετμιν αΰιπθψτψεο αθΰ δξγλΰιν ΰϊ ιςιμεϊ δϊψετδ ξρεβ ζδ μΰεψκ ζξο.

λξε λο, αχψα ξθετμιν ωςαψε μχετχρεο® πξφΰδ ςμιιδ ξωξςεϊιϊ ξ-16% μ-68% αωιςεψ δηεμιν ωμΰ ηεε δϊχσ λμμ μΰεψκ λμ ωμεω ωπεϊ δξηχψ. μςεξϊ ζΰϊ, ωιςεψ βιγεμ ξψωιν ζδ μΰ πξφΰ αχψα ηεμιν ωςαψε αιο δϊψετεϊ δξαερρεϊ ΰιπθψτψεο αθΰ.

"ηεμι θψωϊ πτεφδ αωμα δδϊχτι ωμΰ δωιβε ϊεφΰεϊ ξωαιςεϊ ψφεο αθιτεμ δΰιξεπε-ξεγεμθεψι δψΰωεο, ξψεειηιν μψεα αςϊ ξςαψ μθιτεμ ΰιξεπε-ξεγεμθεψι ξρεβ ΰηψ", ΰξψδ γ"ψ ΰγψιΰπδ χΰψδ, ξδξημχδ δπειψεμεβιϊ ααιϊ δηεμιν αψιθπιχε ααεΰπερ ΰιιψρ, ΰψβπθιπδ, δηεχψϊ δψΰωιϊ αξηχψ. "δϊεφΰεϊ ωδεωβε αχψα ηεμιν ωςαψε ξΰιπθψτψεο αθΰ μχετχρεο® ϊεΰξεϊ μϊεφΰεϊ ξηχψιν χεγξιν ωπςψλε, ΰωψ δγβιξε ιψιγδ ςχαιϊ αωιςεψ δδϊχτιν δωπϊι δξξεφς εδϊιιφαεϊ αδϊτϊηεϊ δξημδ".

ΰεγεϊ δξηχψ
δξηχψ δδωεεΰϊι δψθψερτχθιαι λμμ 114 ηεμι RRMS, αωξεπδ ξψλζιν μθιτεμ αθψωϊ πτεφδ αΰψβπθιπδ. αξδμλε παηπδ ιςιμεϊ δημτϊ δθιτεμ δϊψετϊι αχψα ηεμιν ωμΰ δωιβε ϊεφΰεϊ ξωαιςεϊ ψφεο αθιτεμ δΰιξεπε-ξεγεμθεψι δψΰωεο, αδϊιιηρεϊ μπϊεπι ωιςεψ δδϊχτιν δωπϊι εμωιπει δξξεφς αξγγ δ- EDSS μΰεψκ ϊχετδ ωμ ωω ωπιν . δξηχψ αηο ϊχετϊ θιτεμ ωμ ωμεω ωπιν θψν δημτϊ δθιτεμ εϊχετϊ θιτεμ περτϊ ωμ ωμεω ωπιν μΰηψ δημτϊε. ξωϊϊτι δξηχψ παηψε ξχψα ξΰβψ δξεπδ μξςμδ ξ-1,500 ηεμιν αΰψβπθιπδ. δηεμιν θετμε αΰηγ ξΰψαςϊ δθιτεμιν δαΰιν: IFN?-1a i.m, IFN?-1a s.c (22 ΰε 44 ΅g), IFNB-1b εχετχρεο®. ϊεφΰεϊιε δχμιπιεϊ ωμ δθιτεμ δεςψλε μΰηψ ϊχετδ ψΰωεπδ αϊ ωμεω ωπιν. ηεμιν ωςπε μχψιθψιεπιν δξφαιςιν ςμ λωμεο δθιτεμ δψΰωεο - ςμ τι ϊεφΰεϊ μΰ ξρτχεϊ ΰε ΰι-ραιμεϊ μϊλωιψ, δεςαψε μθιτεμ ξρεβ ΰηψ: ξξιπεο πξεκ μξιπεο βαεδ ωμ ΰιπθψτψεο αθΰ (n=31); ξΰιπθψτψεο αθΰ μχετχρεο® (n=47) ΰε μ-Mitoxantrone (n=13); ΰε ξχετχρεο® μΰιπθψτψεο αθΰ (n=16). ωιςεψ δδϊχτιν δωπϊι αχαεφϊ δξθετμιν ωδεςαψδ ξθιτεμ αΰιπθψτψεο αθΰ μθιτεμ αχετχρεο®, δφθξφν ξ-0.63 μ-0.14, πϊεο δξδεεδ ωιτεψ ωμ 77% P<0.0001)). αχψα δηεμιν ωδεςαψε μθιτεμ α-Mitoxantrone πψων ωιτεψ ωμ 71%, ξ-0.53 μ- 0.15 P=064)). μςεξϊν, αχψα ηεμιν ωδεςαψε αιο ωπι θιτεμιν ωεπιν αΰιπθψτψεο αθΰ, πξφΰ ωιτεψ πξεκ ιεϊψ, ωμ 57%, αωιςεψ δδϊχτιν δωπϊι - ξ-0.37 μ-0.16 (P=0.03). αχψα λμ δηεμιν ωδημιτε θιτεμ ςχα ιςιμεϊ μΰ ξρτχϊ, πψωξδ ςμιιδ πιλψϊ θψν δωιπει αρεμν δ-EDSS. ξξεφςι δ-EDSS δξωιλε μςμεϊ αχψα ηεμιν ωδεςαψε αιο ωπι θιτεμιν ωεπιν αΰιπθψτψεο αθΰ (P=0.028) ΰε ξχετχρεο® μΰιπθψτψεο αθΰ (P=0.0059). ξπβγ, αχψα ηεμιν ωδεςαψε ξθιτεμ αΰιπθψτψεο αθΰ μθιτεμ αχετχρεο® ΰε α-Mitoxantrone, ΰσ πψων ωιτεψ ξωξςεϊι αςχαεϊ δξςαψ. δωιτεψ δπξεκ αιεϊψ πφτδ αχψα ηεμιν ωδεςαψε αιο θιτεμιν ωεπιν αΰιπθψτψεο αθΰ. αχψα δηεμιν ωδημιτε θιτεμ ςχα ϊετςεϊ μεεΰι, μΰ πφτδ ωιπει ξδεϊι αξγγ δ-EDSS μΰεψκ ϊχετϊ δθιτεμ θψν δωιπει - αιο ΰν δν θετμε αΰιπθψτψεο αθΰ εαιο ΰν αχετχρεο®. ξξεφςι δ-EDSS πεϊψε ιφιαιν δο αξςαψ ξΰιπθψτψεο αθΰ μχετχρεο® εδο αξςαψ ξχετχρεο® μΰιπθψτψεο αθΰ. ξιγς περσ ΰεγεϊ δξηχψ εϊεφΰεϊιε, πιϊο μχαμ μξφεΰ αξΰξψ: " Therapeutic outcome 3 years after switching of immunomodulatory therapies in patients with RRMS in Argentina", ωτεψρν αβιμιεο ΰτψιμ ωμ διψηεο European Journal of Neurology.

ΰεγεϊ θας θας ϊςωιεϊ τψξφαθιεϊ ας"ξ (πργΰ"χ: TEVA) διπδ ηαψδ βμεαμιϊ ωαριρδ αιωψΰμ, ΰηϊ ξ-20 ηαψεϊ δτψξφαθιχδ δξεαιμεϊ αςεμν εδηαψδ δβπψιϊ δξεαιμδ. θας ξϊξηδ ατιϊεη, ιιφεψ εωιεεχ ϊψετεϊ βπψιεϊ ειιηεγιεϊ, ηεξψιν τςιμιν μϊςωιιδ δτψξφαθιϊ. χψεα μ-80% ξξλιψεϊ δχαεφδ ξψελζεϊ αφτεο ΰξψιχδ εαΰιψετδ. τςιμειεϊ δξε"τ ωμ θας ξϊξχγεϊ ατιϊεη ϊψετεϊ ςαεψ ξημεϊ δτεβςεϊ δξςψλϊ δςφαιν δξψλζιϊ.


Safe Harbor Statement under the U. S. Private Securities Litigation Reform Act of 1995:
This release contains forward-looking statements, which express the current beliefs and expectations of management. Such statements are based on management's current beliefs and expectations and involve a number of known and unknown risks and uncertainties that could cause Teva's future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. Important factors that could cause or contribute to such differences include risks relating to: when and whether the proposed acquisition will be consummated, Teva's ability to rapidly integrate Beryllium's' operations with its own operations and achieve expected synergies, the diversion of management time on merger-related issues, Teva's ability to accurately predict future market conditions, potential liability for sales of generic products prior to a final resolution of outstanding patent litigation, including that relating to the generic versions of Allegra®, Neurontin®, Lotrel®, Famvir® and Protonix®, Teva's ability to successfully develop and commercialize additional pharmaceutical products, the introduction of competing generic equivalents, the extent to which Teva may obtain U.S. market exclusivity for certain of its new generic products and regulatory changes that may prevent Teva from utilizing exclusivity periods, competition from brand-name companies that are under increased pressure to counter generic products, or competitors that seek to delay the introduction of generic products, the impact of consolidation of our distributors and customers, the effects of competition on our innovative products, especially Copaxone® sales, the impact of pharmaceutical industry regulation and pending legislation that could affect the pharmaceutical industry, the difficulty of predicting U.S. Food and Drug Administration, European Medicines Agency and other regulatory authority approvals, the regulatory environment and changes in the health policies and structures of various countries, our ability to achieve expected results though our innovative R&D efforts, Teva's ability to successfully identify, consummate and integrate acquisitions, potential exposure to product liability claims to the extent not covered by insurance, dependence on the effectiveness of our patents and other protections for innovative products, significant operations worldwide that may be adversely affected by terrorism, political or economical instability or major hostilities, supply interruptions or delays that could result from the complex manufacturing of our products and our global supply chain, environmental risks, fluctuations in currency, exchange and interest rates, and other factors that are discussed in Teva's Annual Report on Form 20-F and its other filings with the U.S. Securities and Exchange Commission. Forward-looking statements speak only as of the date on which they are made and the Company undertakes no obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.